Raymond DuBois, M.D., Ph.D.

Professor

Biochemistry & Molecular Biology

Cancer Focus

Elucidating the role of inflammation and inflammatory mediators in the progression of colon cancer

Research Program

Developmental Cancer Therapeutics

Contact

Research Interest

My research is focused on understanding the molecular, genetic, and cellular bases for normal and neoplastic intestinal biology. As part of this focus, my laboratory is interested in understanding how inflammation and inflammatory mediators contribute to colorectal carcinogenesis. Our earlier work uncovered a previously unrecognized role of pro-inflammatory PGE2 in promoting colorectal cancer (CRC) initiation, growth, and metastasis. We showed, for the first time, that PGE2 promoted CRC formation, growth, and metastasis by silencing certain tumor suppressor and DNA repair genes via DNA methylation, inducing cancer stem cell expansion, and modulating the type of immune cells in the tumor microenvironment.

Positions and Scientific Appointments

2023-Present: Associate Provost of Cancer Programs 2020-Present: Director, Hollings Cancer Center 2016-Present: Distinguished University Professor, MUSC, Charleston, SC 2016-2021: Dean of Medicine, MUSC, Charleston, SC 2012-2017: Professor of Medicine, Mayo Clinic College of Medicine, Scottsdale, AZ 2012-2016: Executive Director, Biodesign Institute, Arizona State University, Tempe, AZ 2007-2012: Provost & Executive Vice President, UTMDACC, Houston, TX 2007-2012: Professor of Cancer Biology & Cancer Medicine, UTMDACC, Houston, TX 2005-2007: Director, Vanderbilt-Ingram Cancer Center, Nashville, TN 2003-2004: Hortense B. Ingram Professor, Molecular Oncology, VUMC, Nashville, TN 1998-2003: Director, Gastroenterology, Hepatology & Nutrition, Vanderbilt University Medical Center, Nashville, TN 1996-2004: Director, Cancer Prevention Program, Vanderbilt-Ingram Cancer Center, Nashville, TN 1994-2004: Director, Vanderbilt Digestive Disease Research Center, Nashville, TN 1991-1997: Assistant (1991) Associate (1994) and Full Professor (1997), Vanderbilt University School of Medicine, Nashville, TN

Education

Fellowship

January 1991

Gastroenterology

The Johns Hopkins Hospital, Baltimore, MD

Residency

January 1988

Internal Medicine

The Johns Hopkins Hospital, Baltimore, MD

MD

January 1985

Medicine

University of Texas Health Science Center, San Antonio, TX

PhD

January 1981

Biochemistry

University of Texas Southwestern Medical Center, Dallas, TX

BS

January 1977

Biochemistry

Texas A & M University, College Station, TX

View Full Bibliography