John Lemasters, M.D., Ph.D.

I direct the Hollings Cancer Center (HCC) Cell & Molecular Imaging (CMI) Shared Resource, which also supports the Digestive Disease Research Core Center, and COBREs on “Oxidants, Redox Balance and Stress Signaling” and “Digestive and Liver Disease”. CMI provides training, assistance, and access to 5 confocal/multiphoton/super-resolution microscopes of different configurations and capabilities. I have a long-standing interest in the role of mitochondrial metabolism in pathobiology, especially in relation to alcoholic and non-alcoholic steatohepatitis, oxidative stress, ischemia-reperfusion injury to heart and liver, mitochondrial autophagy (mitophagy), and cancer. My laboratory has published more than 400 papers in peer-reviewed journals (h-index = 118) plus more than 100 book chapters. Productive, long-term collaborations with junior and senior colleagues contributed importantly to this success. For these projects, my laboratory applies new techniques of quantitative laser scanning confocal, intravital multiphoton, and super-resolution microscopy, as well as Seahorse respirometry and related metabolic flux techniques, for physiological analysis of mitochondria and other organelles in living cells and in the intact tissues of living animals.