Michael Marrone, Ph.D.

The focus of my training and professional experiences demonstrates my commitment to applying epidemiologic methods in the translation of biomarker applications into effective cancer prevention and control strategies. Throughout my career I have engaged in multidisciplinary team science collaborations including clinical researchers, laboratory scientists, and other population-based scientists to develop strategies to improve the translation of genomic and non-genomic biomarker applications. My applied research is focused on circulating biomarkers of metabolic function to investigate the underlying molecular mechanisms linking obesity and prostate cancer lethality, as well as the use of common medications to treat metabolic factors. As part of the independent phase of an R00 from NCI, I am leading a multidisciplinary patho-epidemiologic investigation of the immune-modulating effects of statins through YAP-medicated T-reg dysfunction in the prostate tumor microenvironment. The long- term goal of this work is to determine whether statins have an adjuvant role in the context of immune-therapy for men with prostate cancer, and the population-level impact of translating statins into cancer prevention and control strategies.