Hollings Cancer Center Members

Thoracic Medical Oncology

Molecular markers of cancer progression, outcome and therapies

Lymphoma Biology

Statistical design of early phase cancer trials and developing novel dose-finding methodology.

To elucidate the mechanisms by which O-GlcNAc transferase modulates epigenetic regulators contributing to breast cancer stem cell initiation and metastasis

Malignant hematology with a focus in leukemias, myelodysplastic syndromes and hematopoietic stem cell transplantation

Clinical translational trials for head and neck and skin cancers

Development of novel therapeutics for myeloproliferative neoplasms

Identification and molecular characterization of genetic alterations that impact cancer prognosis and therapeutics.

Discovering small molecules and biologics (recombinant protein therapeutics, monoclonal and bispecific antibodies) that serve as tools to interrogate new mechanisms in cancer biology and as potential drug candidates for future development.

Discovery and validation of glycan and glycoprotein biomarkers in tissues, cells and biofluids for prostate, breast, pancreas, colon, kidney and liver cancers

Elucidating the role of inflammation and inflammatory mediators in the progression of colon cancer

Clinical Oncology

Effects and biochemical mechanism of pharmacological targeting ion channels in solid tumors.

Malignant pleural mesothelioma, a rare and aggressive malignancy

My cancer research interest is in clinical trials for urologic cancers (including prostate, bladder, and kidney).

Loco-regional delivery of chemotherapy agents guided by imaging

The discovery and development of new natural product inhibitors of cancer that provide new and unusual targets

Hypofractionated Radiotherapy

Novel Therapeutic Approaches to Pancreatic Cancer

Novel therapeutics in Hodgkin lymphoma (HL) and Diffuse Large B-cell Lymphoma (DLBCL)

Epigenetics of Kidney Cancer

To develop novel therapeutic strategies to overcome immunotherapy resistance in melanoma and other cancers.

Microbiome and cancer

Novel ways to evaluate response to immunotherapy and augment the response of patients to immune directed treatment approaches

Mechanism of anti-SFRP2 therapy in cancer

Neuroblastoma, pediatric sarcomas, pediatric precision medicine and clinical trial development

Clinical related research in Thoracic, GI, and GU malignancies

Cellular and molecular mechanisms of apoptosis and necrosis

Clinical trials in gastric and esophageal cancers

Allosteric control of tyrosine phosphorylation in oncogenic signaling cascades

Clinical Trial Development

Examining the role of the sphingolipid pathway in the progression of osteosarcoma by the non-malignant osteoblasts in the tumor microenvironment

Cancer Biomarkers

How modulation of endogenous interferon pathways in stem-cell derived hepatocytes affects hepatitis B virus, which is a major inducer of hepatocellular carcinoma worldwide

Head and Neck Cancer

Characterization of the pathophysiology of single living cells, including the assessment of ion homeostasis, and other biochemical parameters

Developing novel approaches to inhibit oncogenic RAS

Determining the mechanisms by which alterations in lipid metabolism and signaling regulate cancer growth, proliferation, metastasis, and response to chemotherapy or immunotherapy modalities

I am broadly active in translational science, clinical trials, prevention, novel surgical approaches, and survivorship to improving gynecologic cancers.

Hormone driven and refractory cancers, cell signaling, bioenergetics, general drug discovery, biomarkers

New pathways important in patients with liver disease and the molecular basis of portal hypertension

Surgical Oncology

 Drug delivery of small and large molecules to difficult to access tumors

Elucidating the mechanisms of cancer therapeutics, drug resistance, and metastasis in breast cancer

Breast Cancer Research

To uncover new functional regions and novel drug targets in the RAS-MAPK pathway through the study of rare disease-associated mutations

Drug discovery, medicinal chemistry, and the elucidation of underlying receptor pharmacology to develop new anticancer therapeutics

Redox in drug development and mechanism

Combining advanced proteomics and drug metabolism with biochemistry to identify molecular targets of oxidative and nitrosative stress and to determine how redox modulation impacts protein folding and cell injury

Identification of novel signaling pathways/interaction within cancer cells or cancer-immune cell interactions that can be targeted therapeutically to improve therapy efficacy and/or prevent cancer relapse/recurrence

Prostate, kidney, bladder, testis cancer community-based, translational, survivorship, and outcomes.

Exploring the mechanisms of leukemia infiltration and immune evasion

Lipid metabolic reprogramming in cancer cells as it contributes to tumor progression and cancer disparities

Novel therapeutic strategies and biomarkers for the treatment of non-small cell lung cancer

Hepatology and toxicology, especially on the roles of free radicals and mitochondrial dysfunction in liver injury, inflammation and fibrosis